Association between polymorphisms of the adenylate cyclase 3 gene rs2241759 and the effect of high-intensity interval training on blood lipid profiles
Question
Are ADCY3 rs2241759 polymorphisms associated with lipid responses to 12 weeks of HIIT in Chinese Han college students?
Summary
In 237 Chinese Han college students, 12 weeks of running/walking HIIT improved HDL-C, LDL-C, and triglycerides, while total cholesterol rose slightly overall. The study also found that the ADCY3 rs2241759 polymorphism was associated with LDL-C response.
Methodology
- Chinese Han university students with non-regular exercise habits.
- 237 participants.
- Running/walking.
- Work intervals: 15 seconds to 4 minutes.
- Recovery: 15 seconds to 3 minutes walking.
- Intensity: 80%-90% VO2max work.
- 28 minutes.
- 3 sessions/week.
- 12 weeks.
- Single-group pre/post genetic association training study
- Blood lipids, and Genetic association were tracked.
Outcomes
HDL-C
HDL-C increased after 12 weeks.
+0.276 +/- 0.251 mmol/L, p<0.001.
LDL-C
LDL-C decreased after 12 weeks.
-0.335 +/- 0.417 mmol/L, p<0.001.
Triglycerides
Triglycerides decreased after 12 weeks.
-0.110 +/- 0.382 mmol/L, p<0.001.
rs2241759
rs2241759 was associated with LDL-C response.
p=0.04363 after covariates.
Insights
- A 12-week progression from short intervals to 4 x 4-minute intervals is feasible in a supervised university setting.
- Genetic-response findings are not ready for consumer personalization.
Limitations
- No non-exercise control group.
- Diet was not strictly controlled.
- Healthy young Chinese Han sample limits generalizability.
- Relatively small sample for genetic-response inference.
Safety
- No adverse events were reported.
- Participants completed an exercise risk questionnaire and researchers performed an exercise risk assessment.
- VO2max testing used dynamic ECG monitoring; training sessions used Polar heart-rate monitoring, RPE, and professional supervision.