PMID 37842247

Research
All papers

Influence of 8 Weeks of Tabata High-Intensity Interval Training and Nanocurcumin Supplementation on Inflammation and Cardiorespiratory Health among Overweight Elderly Women

Noorbakhsh S, Roshan VD

Question

Do Tabata HIIT and nanocurcumin supplementation, alone or together, influence inflammation and cardiorespiratory health in overweight sedentary women?

Summary

In overweight sedentary middle-aged to older women, eight weeks of low-frequency bodyweight Tabata-style HIIT, nanocurcumin, or both improved some body-composition, cardiorespiratory, hemodynamic, and inflammatory markers, with the combined group showing blood-pressure improvements.

Methodology

  • Apparently healthy sedentary overweight/pre-obese women.
  • 48 participants.
  • Bodyweight exercises.
  • Work intervals: 20 s according to table.
  • Recovery: 20 s between movements; 60 s between sets.
  • Intensity: 80-90% predicted HRmax; RPE 7 to 8-9.
  • Approximately 27-40 min depending on week.
  • 2 sessions/week.
  • 8 weeks.
  • Double-blind randomized placebo-controlled four-arm trial
  • VO2max, NLRP3, and Blood pressure were tracked.

Outcomes

Inflammation

Active HIIT and/or nanocurcumin arms had lower NLRP3 than placebo.

Placebo increased NLRP3; active groups lower at 8 weeks.

Improved

VO2max

VO2max improved in all groups except placebo.

Between-group differences for VO2max were not significant.

Improved

Blood pressure

Combined Tabata HIIT plus nanocurcumin reduced SBP and DBP from baseline.

SBP p<0.04; DBP p<0.02.

Improved

Insights

  • A low-frequency bodyweight HIIT plan can be structured with set-count progression.
  • Older overweight populations need explicit screening and intensity monitoring.

Limitations

  • Small per-group sample
  • Supplement co-intervention
  • Protocol timing ambiguity
  • Adverse-event reporting not explicit

Safety

  • No adverse events were reported.
  • Safety context included physical examination, vitals, resting ECG, SpO2 screening, continuous ECG/HR/BP/SpO2 during stress testing, and ACC/AHA test termination criteria.
  • Participants not meeting at least 85% training or supplement adherence were eliminated; final dropout reasons were not clearly reported.