PMID 34539437

Research
All papers

Effects of Four Lipid Metabolism-Related Polymorphisms on Body Composition Improvements After 12 Weeks of High-Intensity Interval Training and Dietary Energy Restriction in Overweight/Obese Adult Women: A Pilot Study

Andrade-Mayorga O, Díaz E, Salazar LA

Question

Do lipid-metabolism-related polymorphisms influence body-composition response after 12 weeks of supervised HIIT plus dietary energy restriction in overweight or obese women?

Summary

In overweight or obese adult women, 12 weeks of supervised cycling HIIT plus a calorie-restricted diet reduced body mass and fat mass and improved VO2peak, but the study had no non-exercise control group and diet was part of the intervention. A PLIN1 genotype appeared related to greater fat-loss response, making this mainly internal personalization context rather than a frontend promise.

Methodology

  • Overweight or obese premenopausal adult women
  • 30 participants.
  • Cycle ergometer.
  • Work intervals: 1 minute.
  • Recovery: 2 minutes seated inactive rest.
  • Intensity: 85%-100% HRmax and muscle failure at the end of intervals.
  • 30 minutes.
  • 3 times/week.
  • 12 weeks.
  • Pilot single-arm genotype-response intervention study
  • Fat mass, VO2peak, Genotype response, and Safety were tracked.

Outcomes

Fat mass

Body mass, fat mass, percent body fat, and BMI decreased after HIIT plus diet.

High responders lost about -4.7 kg fat mass versus -1.1 kg in low responders; between-delta p<.0001

Improved

VO2peak

VO2peak and VO2peak relative to fat-free mass increased similarly across responder groups.

Improved

PLIN1

PLIN1 rs1052700 genotype was associated with high versus low fat-loss response, but this was exploratory.

Chi2=8.138, p=.01; TT genotype had greater fat-mass reduction, p=.04

Mixed

Safety

Participants tolerated exercise and no injuries were reported.

Improved

Insights

  • Do not use this as exercise-only fat-loss evidence because diet restriction was part of the intervention.
  • For internal generation, this supports a 10 x 1-minute cycling template with 2-minute rests for medically screened users.
  • Genotype-response findings should remain exploratory and not user-facing personalization claims.

Limitations

  • Small pilot sample
  • No non-intervention control group
  • Not randomized
  • Diet co-intervention confounds exercise-only effects
  • Bioelectrical impedance body composition
  • Women-only overweight/obese sample

Safety

  • All participants tolerated exercise.
  • No injuries were reported.
  • Participants were medically screened and several cardiometabolic conditions were excluded.