PMID 32425570

Research
All papers

Effects of Two Types of Moderate- and High-Intensity Interval Training on Serum Salusin-α and Salusin-β Levels and Lipid Profile in Women with Overweight/Obesity

Nazari M, Minasian V, Hovsepian S

Question

How do 8 weeks of moderate- versus high-intensity cycling interval training affect serum Salusin-alpha, Salusin-beta, and lipid profile in women with overweight/obesity?

Summary

In 40 inactive women with overweight or obesity, 8 weeks of cycling interval training at moderate or high intensity improved selected lipid and salusin biomarkers compared with control. Moderate intensity produced a much larger Salusin-alpha increase, while high intensity produced larger total cholesterol and LDL percentage reductions.

Methodology

  • Inactive women aged 25-35 years with overweight or obesity.
  • 40 participants.
  • Stationary cycling.
  • Work intervals: 30 seconds.
  • Recovery: 30 seconds rest within 2-minute sets; 3 minutes active rest between sets.
  • Intensity: 90-95% HRmax.
  • Varied with progression.
  • 3 sessions/week.
  • 8 weeks.
  • Quasi-experimental matched-group intervention
  • Salusin-alpha, Salusin-beta, Lipid profile, and Body fat were tracked.

Outcomes

Salusin-alpha

Salusin-alpha increased significantly, with a much larger percentage change in MIIT than HIIT.

ANCOVA p=0.001; MIIT +36%, HIIT +3%.

Improved

Lipids

HDL increased and triglycerides and total cholesterol decreased in training groups versus control.

HDL p=0.039; triglycerides p=0.012; total cholesterol p=0.010.

Improved

Salusin-beta

Salusin-beta decreased numerically but was not significant between groups.

ANCOVA p=0.452; MIIT -7%, HIIT -5%.

No clear change

LDL/VLDL

LDL and VLDL decreased numerically, with LDL table marking pre-post change in HIIT, but between-group ANCOVA was not significant for LDL or VLDL.

LDL p=0.108; VLDL p=0.056.

Mixed

Insights

  • 30:30 cycling intervals can be progressed gradually over 8 weeks.
  • Moderate-intensity intervals may be a useful option when high-intensity adherence is difficult.
  • Biomarker improvements should not be presented as proven cardiovascular-event risk reduction.

Limitations

  • Quasi-experimental, not randomized.
  • Diet, menstrual cycle, hormonal changes, and daily activity were not precisely controlled.
  • Adherence and achieved intensity were not reported.
  • Group counts are inconsistent between article text and table.
  • Biomarker outcomes only.

Safety

  • No adverse-event reporting was located in the viewed text.
  • The protocol was piloted on volunteers before the intervention.