# Influence of 8 Weeks of Tabata High-Intensity Interval Training and Nanocurcumin Supplementation on Inflammation and Cardiorespiratory Health among Overweight Elderly Women

PMID: 37842247
Journal: Nutrients
Published: 2023
Authors: Noorbakhsh S, Roshan VD

## Question

Do Tabata HIIT and nanocurcumin supplementation, alone or together, influence inflammation and cardiorespiratory health in overweight sedentary women?

## Summary

In overweight sedentary middle-aged to older women, eight weeks of low-frequency bodyweight Tabata-style HIIT, nanocurcumin, or both improved some body-composition, cardiorespiratory, hemodynamic, and inflammatory markers, with the combined group showing blood-pressure improvements.

## Population

- Apparently healthy sedentary overweight/pre-obese women.
- Sample size: 48
- Age: 40-60 years
- Sex: Female
- Fitness level: Sedentary
- Health status: Apparently healthy, overweight/pre-obese

## Methodology

- Double-blind randomized placebo-controlled four-arm trial
- 8 weeks
- Exercise and clinical testing setting
- Randomized and controlled study design.

## Protocol

- Tabata HIIT.
- Modality: Bodyweight exercises.
- Work intervals: 20 s according to table.
- Recovery: 20 s between movements; 60 s between sets.
- Sets or repetitions: 2-4 sets of 5 min.
- Intensity: 80-90% predicted HRmax; RPE 7 to 8-9.
- Session duration: Approximately 27-40 min depending on week.
- Frequency: 2 sessions/week.
- Program length: 8 weeks.
- Progression: Set count increased over weeks.
- Placebo or nanocurcumin.
- Modality: No exercise in supplement-only/placebo arms.
- Sets or repetitions: Two capsules daily.
- Frequency: Daily supplement/placebo.
- Program length: 8 weeks.

## Outcomes

### Inflammation
Status: improved
Active HIIT and/or nanocurcumin arms had lower NLRP3 than placebo.

Placebo increased NLRP3; active groups lower at 8 weeks.

### VO2max
Status: improved
VO2max improved in all groups except placebo.

Between-group differences for VO2max were not significant.

### Blood pressure
Status: improved
Combined Tabata HIIT plus nanocurcumin reduced SBP and DBP from baseline.

SBP p<0.04; DBP p<0.02.

## Practical Insights

- A low-frequency bodyweight HIIT plan can be structured with set-count progression.
- Older overweight populations need explicit screening and intensity monitoring.

## Limitations

- Small per-group sample
- Supplement co-intervention
- Protocol timing ambiguity
- Adverse-event reporting not explicit

## Safety And Adherence

- No adverse events were reported.
- Safety context included physical examination, vitals, resting ECG, SpO2 screening, continuous ECG/HR/BP/SpO2 during stress testing, and ACC/AHA test termination criteria.
- Participants not meeting at least 85% training or supplement adherence were eliminated; final dropout reasons were not clearly reported.

## Original Sources

- [PubMed](https://pubmed.ncbi.nlm.nih.gov/37842247/) (pubmed)
- [DOI](https://doi.org/10.3390/nu15214502) (doi)
- [PMC full text](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567597/) (full text)

## Agent Guidance

Preserve the paper-level scope of this note. Do not generalize beyond the population, protocol, measured outcomes, and limitations above.